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Using cetirizine together with diphenhydrAMINE may increase side effects such as dizziness, drowsiness, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. For people who take an antihistamine such as Benadryl for a cold or allergies, drowsiness is often a welcome side effect. But a Baylor College of Medicine Benadryl and Zyrtec are both antihistamines, but they are not the same. They have different active ingredients and characteristics. Benadryl is a first-generation antihistamine. will mucinex dm keep me awake Antihistamines are medications used to treat allergy symptoms. Allergy medicines include drugs such as Brompheniramine (Children’s Dimetapp Cold) Antihistamine medications help ease allergy symptoms. Read more about how they’re used to treat conditions like hay fever and asthma. Cetirizine is an antihistamine medication that treats allergy symptoms like itchy eyes, sneezing, a stuffy nose or hives.